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Iopromide Injection

Iopromide Injection
Iopromide Injection
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Product Code : Ultravist
Product Description

Iopromide Injection

The presence of LOCM such as Uttravist in the blood stream encourages lowering of blood\viscosity v ia osmodilution. LOCM passes in to glomerular filtrate. Residual hyperosmolality of filtrate increases osmotic pressure of tubular fluid and reduces water reabsorption. More water is retained in tubules, d iluting and further lowering viscosity of tubular fluid (osmodiuresis-). Preserved GFR and fluid flow through tubules and renal blood vessels.

Key Traits

  •     Pyrogen-Free aqueous solution
  •     Helps diagnose problems with brain, heart, and blood vessels
  •     Nonionic sterile, clear, colorless to slightly yellow
  •     No preservatives

 

Preclinical evidence

Unlike IOCM, LOCM such as Ultravist encourages dilution of blood and urine, lowering in vivo viscosity and preserving renal hemodynamics.

Clinical evidence

Osmodilution and osmodiuresis has seen in patients receiving Ultravist': Marked (~20%) decrease in blood viscosity measure in 10 patients undergoingDSA with Ultravist' 370.

  • Double-blind, randomized trial data illustrate increased renal dilution of CM in patients receiving
  • Ultravist compared to those receiving IOCM iodixanol. Lopromide Injection
  • IOCM iodixanol ( ~290 mosm/kgH2O)
  • IOCM iodixanol is iso-osmola to blood.
  • Dilution of blood and urine is not encouraged
  • Viscosity of blood and urine is increased
  • Renal hemodynamics become impaired
  • Viscosity,Osmodiuresis,Kidney Retention, and Renal Damage:
  • Preclinical and Clinical Evidence
  • Ultravist causes less of an increase in urine viscosity compared to IOCM and may therefore better preserve urine flow

Clinical data

In humans undergoing cardiac intervention, compared to IOCM iodixanol, LOCM Ultravist

  • Causes significantly
  • Less of an increase in urine viscosity
  • Less of a decrease in urine production

 

 


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